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Schizophrenia: Scientific Progress
Edited by S. Charles Schulz & Carol A. Tamminga
Oxford University Press 1989, Presumed First Edition
Hardcover 418 pages, Measures 9.5 x 7 inches, Weighs 2 pounds 2 ounces

Condition: Good.
two or three pages are underlined, but that's it, and even those pages are completely legible.
Slightly blemished covers, from storage (dust and such)
Inner pages are clean, white, text is crisp and illustrations are bright.

PREFACE AND CONTENTS:

Preface
The impact of schizophrenia has been addressed repeatedly in recent years by researchers,
clinicians, and policymakers. It is a common disease with a 1% prevalence rate that has a
devastating effect on its victims and their families. One in 10 schizophrenic patients end
their own lives, few are able to function in competitive employment while most need ex-
tended hospital or clinic support, and most families bear high emotional and financial
burdens related to the illness.
Despite the serious impact of schizophrenia on our society, there have been a number
of obstacles to sustained progress in finding cause(s) and in developing better treatment
methods. It has been difficult to attract and retain young investigators and medical collab-
orators. Funding for schizophrenia research has not been commensurate with its severity.
In addition, there is the fundamental problem of carrying out research with individuals
who have a psychotic illness.
Yet, many opportunities in schizophrenia research are open, not the least of which is
active support from citizens' groups for scientific approaches to the illness. The burgeoning
research effort in neurobiology has provided us with sophisticated information about
neural processes, and in some cases detailed knowledge of specialized brain functions.
Similarly, the methods available for the rigorous study of individuals with schizophrenia
have come of age. Thus, we have brain imaging and molecular genetics as well as the more
traditional biochemical, anatomic, and observational techniques. Newer and more specific
drugs are now available for testing in schizophrenia, and others are in development. In
many ways, it is a promising time for the study of schizophrenia.
To facilitate the research process in this field, a number of conferences have been held
in the past decade. These include the Rochester Schizophrenia Conference (1976), the
APPA (1984), and three Biannual Winter Workshops on Schizophrenia that were begun
in 1982. We were impressed at the 1986 Winter Workshop by the spirit of the investiga-
tors, the critical mass, and the lively, international exchange of information. This led to
ing the organization of which was of held The March International 28—April Congress 1, 1987. on A Schizophrenia number of prominent Research, neuroscientists the first meet-
were invited to discuss their areas of expertise as a fundamental basis for the applied re-
search discussions. Young investigators interested in careers in schizophrenia research
were given travel awards and seasoned clinical researchers discussed their latest findings
and directions for future work.
Before the meeting we began planning a book that could stand as a statement of the
progress made in schizophrenia research. To accomplish this goal we decided to organize
a series of chapters focused on topics where significant advances had been made in recent
years. Our idea was not to publish a comprehensive textbook on schizophrenia or an ex-
haustive review, but rather was it to ask the authors to provide up-to-date reports of re-
search in their areas and to speculate about the hopes for the future.
The book is designed to be helpful to a variety of audiences. It is divided into eight
sections that enable the reader to compare and contrast various approaches in each dis-
cipline. Each section has an introduction by the editors that attempts to provide some
historical perspective and to describe the relevance of the individual chapters. Thus, we
feel that the book will offer useful views of the state-of-the-art to active schizophrenia
researchers and be a valuable source of information for psychiatric residents and faculty
as well as neuroscientists interested in collaborating with schizophrenia researchers.
."4 114144
PREFACE
vi
Our hope in organizing the
International Congress on Schizophrenia Research and ed-
iting this volume has b
i
een to
provide an atmosphere conducive to advancement n re-
search in schizophrenia. We are
indebted to the authors for investing their time and
thought i n this effort.
Rockville, MD
Baltimore, MD
January 1989
S.C.S.
C.A.T.
Contents
Introduction: Biomedical Models and Schizophrenia Research
S.J. Keith, S.C. Schulz, and D. Shore
I. CLASSIFICATION AND EPIDEMIOLOGY
1. Domains of Psychopathology Relevant to the Study of Etiology and
Treatment in Schizophrenia
W.T. Carpenter, Jr., and R.W. Buchanan
2. Drawing the Boundary of the Schizophrenia Spectrum: Evidence from a
Family Study
M.T. Tsuang and M.J. Lyons
3. Comparison of Winter- and Summer -Born Schizophrenics and Winter-
and Summer -Born Affectives
R.E. Kendell and LW. Kemp
4. Cultural Variations in the Treated Prevalence Rate and Syrnptomatology
Among Chinese, Japanese, Fillipino, and Caucasian Schizophrenic
Patients in Hawaii 36
F.T.L. Leong
5. The Epidemiology of Schizophrenia: Questions Needing Answers 45
E.F. Torrey

H. VULNERABILITY FACTORS
6. Obstetric Complications and Schizophrenia: Methodology and
Mechanisms 56
S.W. Lewis, M.J. Owen, and R.M. Murray
7. Disturbances of Fetal Neural Development and Adult Schizophrenia 69
S.A. Mednick, R.A. Machon, and M. Huttunen
8. Neurologic Soft Signs in an Epidemiological Sample of First Admission
Psychotic Patients: A Preliminary Analysis
A.E. Pulver, R.W. Buchanan, B.W. Thompson, J. McGrath, and P.S. Wolyniec
9. Attentional Markers of Schizophrenia: Evidence from the New York
High -Risk Study
B. Cornblatt, L. Winters, and L. Erlenmeyer-Kimling
HI. NEUROPSYCHOLOGY AND NEUROPHYSIOLOGY
10. Sustained, Focused Attention Under High Processing Loads: Relevance to
Vulnerabi l ity to Schizophrenia
K.H. Nuechterlein, N. Garmezy, and V.T. Devine
VIII 1
11. Cognitive Markers for Schizophrenia: An Appraisal
M.E. Strauss
12. Eye Tracking and Skin Conductance in Schizophrenia: The Role of
Nueroleptics and Tardive Dyskinesia
H.E. Spohn, L. Coyne, and J. Spray
13. Oculomotor Performance in Schizophrenic Illness
G.K. Thaker, R. Buchanan, B. Kirkpatrick, and C.A. Tamminga
14. Sensorimotor Gating and the Neurobiology of Schizophrenia: Human
and Animal Model Studies
D.L. Braff and M.A. Geyer
IV. BASIC STUDIES AND ANIMAL MODELS
15. Animal Models of Schizophrenic Disorders
W.T. McKinney
16. The Phencyclidine Receptor Complex: Interaction with Excitatory Amino
Acids and Endogenous Ligands
J.B. Monahan, P.C. Contreras, T.H. Lanthorn, D.A. DiMaggio, G.E. Handelmann, L.M.
Pullan, N.M. Gray, and T.L. O'Donohue
17. Limbric System: Localization ofPCP Drug Action in Rat and
Schizophrenic Manifestations in Humans
C.A. Tannminga, G.K. Thaker, L.D. Alphs, and T.N. Chase
18. Schizophrenia and Epilepsy
J.R. Stevens
19. A Possible Animal ModelofDefect State Schizophrenia
R.J. Wyatt, R. Fawcett, andD. Kirch
V. IMAGING AND LOCALIZATION
20. Cerebral Ventricular Enlargement in Schizophrenia: Prevalence and
Correlates 195
C.L. Cazzullo, A. Vita, and E. Sacchetti
21. Magnetic Resonance Imaging inSchizophrenia: An Update 207
N.C. Andreasen, J. Ehrhardt, W. Yuh, V. Swayze, S. Ziebell, and G. Cohen
22. Limbic and Paralim bic Pathology in Schizophrenia: Interaction with Age-
and Stress -Related Factors 21(
B. Bogerts
23. An Orientation to Work on the Prefrontal Cortex in Schizophrenia 227
T.E. Goldberg, K.F. Berman, and D.R. Weinberger
24. Relative Metabolic Rate in Frontal Lobes of Normals and Schizophrenics
Assessed by Positron Emission Tomography
24,
M.S. Buchsbaum and E. Hazlett
VI. NEUROCHEMISTRY
25. Postmortem Neurochemistry Studies in Schizophrenia
264
G. Jaskiw and J. Kleinman
CONTENTS
ix
26. Quantitation of Neuroreceptors in Living Human Brain: Implications for
Schizophrenia Research
D.F. Wong, A. Gjedde, L.E. Tune, V. Villemagne, J.M. Links, R.F. Dannals, and H.N.
Wagner, Jr.
27. Clinical and Biochemical Effects of Neuroleptic Treatment: Implications
for the Pathophysiology of Schizophrenia
D. Pickar and A. Breier
28. Clozapine: Clinical Advantages and Biologic Mechanisms
H.Y. Meltzer
29. Some Clinical and Biochemical Predictors of Early Neuroleptic Response
M.B. Bowers, M.E. Swigar, P.I. Jatlow, and N. Goicoechea
VII. TREATMENT
30. Psychosocial Treatment of Schizophrenia 318
M.J. Goldstein
31. Haloperidol Plasma Levels and Clinical Response: A Therapeutic Window
Relationship 325
T. Van Putten, S.R. Marder, J. Mintz, and R.E. Poland
32. Intermittent Medication in Schizophrenia: A Preliminary Report 333
M.I. Herz, W. Glazer, M. Mirza, M. Mostert, H. Hafez, P. Smith, E. Trigoboff, D. Miles, J.
Simon, and J. Finn
33. Nonresponders to Neuroleptics: A Distinct Subtype 341
S.C. Schulz, R.R. Conley, E.M. Kahn, and J. Alexander
34. Strategies for Treating Nonresponding Schizophrenics 351
G.M. Simpson and W.H. Wilson
35. Cognitive Treatment of Basic Pervasive Dysfunctions in Schizophrenia 358
H.D. Brenner, W. Böker, B. Hodel, and H. Wyss
VIII. MOTOR DEFECTS
36. Motor and Cognitive Disturbances in Schizophrenic Disorders 372
T.C. Manschreck
37. Tardive Dyskinesia: New Research 381
J. Kane, J. Lieberman, M. Woerner, M. Borenstein, and J. Alvir
38. Are the Effects of Chronic Neuroleptic Therapy Different from Those
Occurring on Acute Administration?
P. Jenner and C.D. Marsden
39. Association of Cognitive Dysfunction, Altered Brain Morphology, and
Release of Developmental Reflexes with Tardive Dyskinesia in
Schizophrenia and Bipolar Affective Disorder
J.L. Waddington, H.A. Youssef, D.J. King, and S.J. Cooper
40. Adrenergic Agents in the Treatment of Neuroleptic-Induced Akathisia
L.
Adler, B. Angrist, S. Reiter, E. Peselow, and J. Rotrosen
Index

Schizophrenia: Scientific Progress S. Charles Schulz & Carol A Tamminga Oxford University Press 1989 First Edition Mental Health Psychology

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